How Have Animals Been Affected By Endocrine Disruptor Chemicals Spilled By Humans?

Endocrine Disruption Endocrine Disrupting Chemicals The Hormones Androgens Corticoids Estrogens Progestins Thyroid Actions Docking: Receptor Binding Delivery: Transport Proteins Disposal: Metabolic Changes Dynamics: Interactions Wildlife Effects Man Effects Sources Phytoestrogens Gathering Evidence What Does ED Mean? Endocrine System Hormone Glands Target Cells Types of Hormones Feedback Loops Glossary

Wild animals Effects Lifelong Effects Altered States Invertebrates Fish Amphibians Reptiles Birds Mammals References Many synthetic chemicals are widely used, exercise non easily breakup, and are moved most by current of air, water, and animals. The chemicals, and sometimes their more harmful breakdown products, pollute soil, h2o, plants, and animals on every continent. Wildlife tin can and do accumulate many of the long-lasting chemicals (the PCBs, dioxins, and organochlorine pesticides) in their fat and frequently pass them along to offspring and predators. Exposure to other less persistent toxic chemicals, such as atrazine, alkylphenols, and tributyltin, is too widespread. At doses found in the environment, some of these ubiquitous chemicals can impact an animal's endocrine system, especially during critical developmental stages. These endocrine disrupting chemicals (EDCs) interfere by mimicking, blocking, or altering hormones and their signaling systems. Pinpointing trouble is catchy because distinct health effects occur among different species, in different organs, and at different life stages. Establishing cause and effect in wild fauna has been hard and even controversial. Since all wild populations are exposed to a variety of pollutants and other stresses, fingering one pollutant or class of pollutants requires extensive sleuthing. Wildlife researchers provide testify nearly exposure and effects by observing, testing, and conducting laboratory experiments to answer questions, such as: Does the hormone problem occur at the same time and place as the pollutant but not in its absence? Does a particular pollutant cause like bug when given in a controlled laboratory setting? Are hormone-related problems plant in dissimilar wild populations in different places and at unlike times? Lifelong Effects Studies of cell cultures, laboratory animals, wildlife, and accidentally exposed humans testify EDCs can cause a wide range of reproductive, developmental, growth, and behavior problems. Near of these adversities are traced to estrogen, androgen, antiandrogen, and antithyroid actions. Less studied are interactions with other hormones and possible effects on immunity (infections), metabolism, (obesity), the brain (intelligence, behavior), the heart, the lungs, and multiple generations (Guillette In Press). Explanation: Chemical pollutants can permanently impact the lifelong health of developing animals, like this turtle hatchling. click here to read more most Gathering Show... Some identified effects of EDCs in wildlife include: aberrant blood hormone levels; masculinization of females; feminization of males; intersex; deformities; abnormal and malformed reproductive organs; embryo mortality; skewed sex ratios; reduced fertility; altered sexual beliefs; modified immune system; contradistinct thyroid functions; brain and neurological problems; reproductive tissue cancers; and altered os density and structure Fetuses and embryos, whose growth and evolution are highly controlled by the endocrine system, seem specially vulnerable to exposure (Bern 1992). Mothers can laissez passer contaminants to their offspring prenatally in eggs (fish, amphibians, reptiles, birds) or the womb (mammals) and afterwards birth past breastfeeding newborns. Exposed adult animals may non show ill effects, only their offspring may have overt or subtle lifelong wellness and/or reproductive abnormalities. back to top Altered States Generally, wild fauna can exist feminized, masculanized, or reproductively suppressed past EDCs. Feminized means males produce more than estrogen then normal. This imbalance leads to puny male secondary sex characteristics (faint coloration, small penis, or lackluster courtship behavior), intersex reproductive organs (part female ovary, part male testis), and possible low fertility. Feminization is well documented in fish and alligators living in highly contaminated water. Females can be masculinized. That is, they develop male secondary sex characteristics, especially penises or penis-like organs. They may also have skewed hormone levels, poorly defined or smaller female reproductive organs, and reduced fertility. back to top Invertebrates Female person snails should not have a penis. But, some of these marine invertebrates, peculiarly snails and other mollusks, living in coastal areas around the globe developed the male reproductive organ after being exposed to the organometal tributyltin (TBT). TBT is an ingredient in anti-fouling paint used to rid boats and ships of barnacles and other unwanted hitchhikers. Even at very low concentrations (1 part per billion), TBT causes female snails to grow a penis that blocks their egg-releasing duct. The females produce eggs that cannot be fertilized and released. In the 1980s and 1990s, populations of littoral marine snails in Europe, North America, and Asia dwindled speedily. In response to this problem, TBT is at present restricted to employ on ships longer than 25 meters (75 feet). TBT concentrations in harbor sediments are lower and many of the afflicted populations are slowly recovering (Evans 1999). back to superlative Fish Worldwide, EDCs feminize, masculanize, and suppress reproduction in wild fish. Widespread feminization occurs in the United Kingdom (UK). Male fish with feminine characteristics are plant near freshwater municipal sewage outlets in England. The fish have intersex organs that produce fewer motile sperm than normal testes, have skewed claret levels of the estrogen hormone estradiol, and have livers that produce vitellogenin, an egg-yolk protein normally found at extremely depression levels in males. Not surprisingly, these intersex males had very low sperm counts and were less fertile than normal males (Jobling and Sumpter 1993; Jobling et al. 1998, 2002a, 2002b). CAPTION: EDCs have various furnishings on many fish species, including the roach (Rutilus rutilus). CREDIT: Wikimedia. Two groups of compounds are the most probable culprits: the alkylphenols (breakdown products of chemicals plant in detergents and plastics) and natural and synthetic estrogens, including 17-beta-estradiol, estrone, and 17-alpha-ethinylestradiol (Desbrow et al. 1998; Jobling and Sumpter 1993; Routledge et al. 1998). In at least one case, adding more effluent processing to remove the suspected toxic compounds reduced the estrogen-mimicking capacity of the domestic and industrial treated sewage released into England's Aire River, England (Sheahan et al. 2002). Fish in UK's estuaries and oceans as well have intersex reproductive organs, make vitellogenin, and some fifty-fifty have feminized genitals (Kirby et al. 2004; Matthiessen et al. 2002). Merely, little fertility data be, so population consequences are largely unknown. Masculinized females occur in some rivers in the United States. Female person mosquitofish living downstream from papermill wastewater outfalls in the southeast develop male genital organs and male courtship behavior (Bortone et al. 1989; Howell et al. 1980). This credible sexual activity alter is only superficial, every bit masculinized females accept ovaries and give nascency to live babies, just like normal females of this species (Bortone and Davis 1994). How the physical and beliefs alterations might affect reproduction and populations is still unclear. What exactly masculinizes the fish is non known. Establish chemicals called sterols (cholesterol-like fats) released from cooked wood pulp are the prime suspects. Bacteria in the h2o and river sediments catechumen the sterols to male androgen hormones, which then contaminate the water and influence fish development (Jenkins et al. 2001, 2003). Pulp and paper mill effluents tin also suppress or inhibit reproductive capacity in male and female person fish. Certain species of wild fish in Canada, Norway, Sweden, and the US have lower sexual activity hormone levels, take longer to reach puberty, and accept reduced fertility. The effluents' endocrine disrupting capability remains later on eliminating chlorine bleaching and improving treatment. This again suggests that compounds present in the wood itself are responsible (Munkittrick et al. 1998). Current efforts are focused on identifying the culprit and developing treatment methods to remove it (Hewitt et al. 2002). back to top Amphibians Wild frogs in the The states suffer from sexual disruption. Up to 9% of cricket frog populations in Illinois are intersex. That is, the frogs accept eggs in the testis or accept one complete testis and one complete ovary, instead of the normal two testes or two ovaries (Reeder et al. 2005). Ten - 90 per centum of male person northern leopard frogs nerveless in 2001 in the upper Midwest also had eggs in the testis (Hayes et al. 2003). Preserved museum specimens and laboratory experiments suggest the intersex conditions are not normal frog sexuality and are probably due to organic pollutants. CAPTION: Environmental chemicals tin adversely affect northern cricket frogs and other amphibians. CREDIT:Wikimedia A team of researchers studied hundreds of preserved museum specimens of cricket frogs collected in Illinois over the past 150 years (Reeder et al, 2005). Only i percent of frogs collected between 1852 and 1929—before industrial and agricultural apply of organochlorine chemicals—were intersex. Between 1946 and 1959, the period of heaviest organochlorine apply, 17 percent of frogs were intersex. Coincident with decreased use and banning of Dichloro-diphenyl-trichloroethane and PCBs, the frequency of intersex frogs declined to ix percent betwixt 1980 and 1996. Over the entire 150 years, intersex cricket frogs were most prevalent in northeastern Illinois, the nigh heavily industrialized and urbanized part of the state. Since 1960, almost no cricket frogs accept been nerveless in this region, strongly suggesting that sexual disruption led to local extinction of cricket frogs. Northern leopard frogs beyond the United States' upper Midwest feel varying degrees of sexual disruption. The suspected culprit may be the herbicide atrazine (Hayes et al. 2003). Collection sites with 0.2 - 6.vii parts per billion atrazine in the water had 10 - 90 per centum intersex males, while the only site with 100 percent normal males had less than 0.2 parts per billion atrazine. Leopard frog tadpoles exposed to atrazine (0.ane or 25 parts per billion) in the laboratory too adult eggs in the testes (Hayes et al. 2003). Caption: Northern leopard frogs exposed to chemicals in the wild and in the lab class abnormal sexual practice organs. CREDIT: © 1979 Alan Resetar Whether intersex cricket and leopard frogs are feminized males or masculinized females is difficult to discern considering the frogs' genetic sex have not been adamant. Some evidence suggests that the intersex cricket frogs are masculinized females. Where intersexes are found, the proportion of females drops, but the proportion of males remains at the expected 50 per centum. The leopard frog male, female, and intersex ratio has not been reported. back to peak Reptiles EDCs' toxic effects are well documented in turtles and alligators. Ane of the almost well known examples is from alligators living in Florida'due south Lake Apopka. The animals were exposed to the estrogenic pollutants dicofol and Ddt and its metabolites, DDD, DDE, and chloro-Ddt, after an extensive chemical spill in 1980. The lake's alligator population plummeted during the side by side 10 years. Explanation: Reproductive furnishings in Florida's alligators are well documented. Researchers investigated and found many health and hormone anomalies in the lake'southward predatory reptiles. Eggs and newborn alligators had higher than normal mortality. The eggs were loaded with high concentrations of p,p'-DDE, p,p'-DDD, and other organochlorine pesticides. Teenaged females had severe ovarian abnormalities and blood estrogen levels 2 times higher than normal. The male juvenile alligators were feminized. They had smaller than normal penises, abnormal testes, and higher estrogen and lower testosterone levels in their blood than normal males of the same age. The researchers concluded that chemicals from the spill not only killed developing eggs outright but besides altered the embryos' hormone levels and sexual development, which severely express reproduction (Guillette et al. 1994, 1995). In a laboratory follow-up study, several of the same chemicals measured in Florida'due south wild alligator eggs were applied to turtle eggs. The pollutants inverse blood hormone levels and sexual development in the red-eared slider turtles. Some, but not all males, became females (Willingham and Crews 1999). Males dosed with chemicals earlier hatching had lower claret levels of testosterone than normal males. Females had lower progesterone and testosterone. Estrogen was so low in both the normal and chemically exposed young turtles that information technology could not be measured (Willingham et al. 2000). Explanation: Sex organ and bone problems are found in snapping turtles exposed to long-lasting toxic compounds in the environs. CREDIT: Wikimedia. Other turtles also show effects from exposure to EDCs. Snapping turtles living in wetlands of Ontario, Canada'southward Great Lakes region are exposed to organochlorine pollutants, primarily PCBs and pesticides. Even though most of these contaminants are at present banned, the residues still linger. Turtle eggs in contaminated wetlands contain 100 - 150 times more pollutants than eggs in uncontaminated marshes. Like Florida's alligators, external sexual differences between male and female person snapping turtle juveniles and adults are macerated. Dissimilar alligators, estrogen and testosterone levels are normal and populations at the contaminated sites are healthy, even though contaminant exposure increases the incidence of skeletal deformities (de Solla et al. 1998, 2002; Bishop et al. 1998). The xanthous-blotched map turtle is classified equally threatened throughout its range of southern Mississippi. Although sexual development is not obviously affected, adult turtles carry PCBs and DDTs in their liver, fat, and muscle (Kannan et al. 2000),. Males captured from a contaminated site had lower claret levels of testosterone than normal males. A small percentage of these males had female-like levels of estrogen (Shelby and Mendonca 2001). dorsum to peak Birds Since the 1950s, fish-eating and predatory bird populations have suffered a multifariousness of health problems due to organochlorine pollutants, including poor reproductive success, growth retardation, and goiter (an over-sized, over-worked thyroid gland). The birds are burdened with a stew of organochlorines, particularly p,p'-DDE and PCBs. CAPTION: Eggshell thinning, caused by toxic chemicals, severely affected bald eagle populations. CREDIT: U.Southward. Fish and Wild animals Service. Reproductive failure in baldheaded eagles, brownish pelicans, gulls, and other birds of prey during the 1970s through the early 1990s was mainly due to eggshell thinning caused by p,p'-DDE (a breakdown chemic of the pesticide DDT). How p,p'-DDE thins eggshells has been studied and debated since the 1970s. One well-accepted explanation is that the chemic blocks the cellular betoken that allows the eggshell gland to eolith calcium in the shell (Bowerman et al. 2000; Dawson 2000; Lundholm 1997). The birds' fates improved later the ban of DDT in the U.s. and Europe. p,p'-DDE concentrations in the native birds take declined, eggshell thickness has improved in nearly species, and populations are recovering. Yet, Ddt is still produced and used extensively in tropical regions to control malaria-carrying mosquitoes. Since these chemicals are long-lived and ubiquitous, bird life around the world is nevertheless at risk from the pollutants. Yet, even though there are improvements, birds of prey and fish-eating birds in the Dichloro-diphenyl-trichloroethane-banned countries are withal plagued past reproductive problems associated with p,p'-DDE and PCB torso burdens. And, some species seem to exist more sensitive than others. Baldheaded eagles about the Great Lakes still have high blood levels of PCBs and p,p'-DDE and have fewer chicks successfully leaving the nest than eagles from inland populations with lower blood levels of chemicals (Bowerman et al. 2000). Explanation: High levels of persistent compounds are usually found in gulls and other fish-eating birds. CREDIT: PickPik. College PCB concentrations in the blood of nesting glaucous gulls are linked to worse parental care. The male and female gulls are absent from the nest more ofttimes and for longer periods (Bustnes et al. 2001). In contrast, egg concentrations of PCBs eight times college than those found in the almost contaminated gulls had no effect on hatching or survival of young dippers (a small songbird) (Ormerod et al. 2000). Although organochlorines clearly cause serious reproductive problems in wild birds, in that location is niggling prove that sexual development is permanently affected. In the laboratory, p,p'-DDE and other DDT metabolites stimulated egg and sperm germ cells to drift into a more than female-similar position in the testes of male Western gull embryos. At hatching, some male person embryos even had oviducts (the tubes connecting an ovary to the genitals) (Fry and Toone 1981). No developed gulls with feminized testes or oviducts were collected in wild populations. In another instance, researchers studied a common tern breeding colony in Massachusetts' Buzzard's Bay to examination whether early signs of feminization might bespeak connected abnormal sexual development. Many of these birds feed nearly New Bedford Harbor at a site heavily contaminated with PCBs. Their eggs take very high PCB concentrations, similar to those constitute in bald eagles incapable of reproducing. Approximately half of the just-hatched male tern chicks had germ cells bundled in a female-similar pattern, but no oviducts. No 21-mean solar day-old male chicks had female-similar tissue in the testis nor did any adult males have ovarian tissue in the testis. The researchers concluded that gonad feminization was temporary and unlikely to compromise reproduction (Hart et al. 2003). back to top Mammals Marine mammals, including seals, body of water lions, porpoises, dolphins, and some whales, living in the world's oceans have high concentrations of organochlorine pollutants such as PCBs and pesticides stored in their blubber (Fossi et al. 2003; Le Boeuf et al. 2002; Tanabe 2002). Except for plankton-feeding whales, marine mammals are superlative predators who accumulate the pollutants from their contaminated prey. Because the contaminants stay associated with fat they are passed forth to nursing young in the mother'due south milk. CAPTION: Skewed hormone levels and reproductive bug plague harbor seals and other marine mammals. Trunk burdens of PCBs and polybrominated diphenyl ethers (PBDEs, a type of flame-retardant) are associated with altered reproductive and thyroid hormone levels. Seals fed organochlorine-contaminated fish from the Wadden Sea (Netherlands) during the early 1980s ovulated and had normal blood levels of estrogen and progesterone. Withal, only xxx percent became meaning compared to 83 percent of seals fed uncontaminated fish (Reijnders 1986). Seals fed an experimental diet of PCB-contaminated fish had lower than normal levels of thyroid hormones in their blood (Brouwer et al. 1989). Wild grayness seals off the Scottish declension have PBDEs in their blubber and unlike the PCB case, seals with more PBDEs have higher thyroid hormone levels (Hall et al. 2003). Polar bears are ultra-top predators. They eat the seals and killer whales that have accumulated big body burdens of PCBs and organochlorine pesticides. As a event, polar bears can have very loftier concentrations of pollutants in their blood and fat. In a heavily contaminated population of polar bears in Svalbard, Norway, a suite of hormonal changes is linked with the total blood levels of PCBs and organochlorine pesticides. Explanation: Polar bears and other acme predators accrue pollutants from their prey. CREDIT: New Zealand Herald Female bears with higher contaminant burdens accept higher blood levels of progesterone, but similar estrogen levels when compared to females with low contaminant burdens (Haave et al. 2003). More heavily contaminated male bears accept lower blood testosterone levels (Oskam et al. 2003). Regardless of historic period and sex, bears with college contaminant burdens have lower blood levels of cortisol (stress hormone) and thyroid hormones (Oskam et al. 2004; Skaare et al. 2001). The implications of these hormonal disruptions are not fully understood, but the Svalbard polar bears have a low reproductive charge per unit compared to other populations (Wiig 1998). Whether low fertility is due to contaminant-related hormone bug or to differing population historic period structure and nutritional condition is a source of continuing research and debate (Haave et al. 2003). Laboratory experiments using rats assistance tease autonomously how PCBs meddle with thyroid hormones. The pollutants do not deceive the thyroid receptor. Instead, they derail commitment of thyroid hormone to the cells by attaching to thyroid transport proteins in the claret, pushing off thyroid hormone. Liver enzymes dispose of the free-floating thyroid hormones. In a double-whammy event, PCBs also rev up activity of these disposal enzymes. The internet event is abnormally depression levels of thyroid hormone in blood. click here to read more well-nigh Actions :: Commitment... dorsum to top References Bern H. 1992. The fragile fetus. In: Chemically-induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection, pp. 9-15. Eds T. Colborn and C. Clement. Vol 21. Princeton. NJ:Princeton Scientific Publishing Co. Bishop C, Ng P, Pettit 1000, Kennedy S, Stegeman J, Norstrom R, and Brooks R. 1998. Ecology contamination and developmental abnormalities in eggs and hatchlings of the common snapping turtle (Chelydra serpentina serpentina) from the Keen Lakes-St Lawrence River basin (1989 - 1991). Environmental Pollution 101:143-156. Bortone S and Davis West. 1994. Fish intersexuality as indicator of environmental stress. Bioscience 44:165-172. Bortone SA, Davis WP, and Bundrick CM. Morphological and behavioral characters in mosquitofish as potential bioindication of exposure to kraft factory effluent. Bulletin of Environmental Contaminants and Toxicology 43:370-377. Bowerman W, Best D, Grubb T, Sikarskie J, and Giesy J, 2000. Assessment of environmental endocrine disruptors in baldheaded eagles in the Great Lakes. Chemosphere 41:1569-1574. Brouwer A, Reijnders P, and Koeman J. 1989. Polychlorinated biphenyl PCB-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal Phoca vitulina. Aquatic Toxicology xv:99-105. Bustnes J, Bakken V, Erikstad K, Mehlum F, and Skaare J.2001. Patterns of incubation and nest-site attentiveness in relation to organochlorine (PCB) contamination in glaucous gulls. J Applied Environmental 38:791-801. Dawson A. 2000. Mechanisms of endocrine disruption with item reference to avian wildlife: a review. Ecotoxicology nine:59-69. Desbrow C, Routledge J, Brighty GC, Sumpter JP, and Waldock M. 1998. Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environmental Scientific discipline and Technology 32:1549-1558. de Solla S, Bishop C, Van Der Kraak G, and Brooks R. 1998. Touch of organochlorine contamination on levels of sexual practice hormones and external morphology of common snapping turtles (Chelydra serpentina serpentina). Environmental Health Perspectives 106:253-260. de Solla S, Bishop C, and Brooks R. 2002. Sexually dimorphic morphology of hatchling snapping turtle (Chelydra serpentina) from contaminated and reference sites in the Great Lakes and St. Lawrence River bowl, Northward America. Environmental Toxicology and Chemistry 21:922-929. Evans Due south. 1999. Tributyltin pollution: The catastrophe that never happened. Marine Pollution Bulletin 38:629-636. Fossi Thou, Marsili 50, Neri Thousand, Natoli A, EP, and Panigada S. 2003. The utilise of a non-lethal tool for evaluating toxicological hazard of organochlorine contaminants in Mediterranean cetaceans: new information 10 years after the first paper published in MPB. Marine Pollution Bulletin 46:972-982. Fry DM and Toone CK. 1981. DDT-induced feminization of gull embryos. Science 213:922 - 924. Guillette LJ, Jr., Gross TS, Masson GR, Thing JM, Percival HF, and Woodward AR, 1994. Developmental abnormalities of the gonad and abnormal sex activity hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environmental Health Perspectives 102, 680-688. Guillette LJ, Jr. 1995. Endocrine disrupting environmental contaminants and developmental abnormalities in embryos. Man Ecological Risk Assess 1:25-36. Guillette LJ, Jr. In Press (2006). Endocrine Disrupting Contaminants: Beyond the Dogma. Environmental Wellness Perspectives. Haave M, Ropstad Eastward, Derocher A, Lie E, Dahl E, Wiig O, Skaare J, and Jenssen B. 2003. Polychlorinated biphenyls and reproductive hormones in female polar bears at Svalbard. Environmental Health Perspectives 111:431-436. Hall A, Kalantzi O, and Thomas Grand. 2003. Polybrominated diphenyl ethers (PBDEs) in grey seals during their showtime year of life: Are they thyroid hormone endocrine disrupters? Environmental Pollution 126:29-37. Hart C, Nisbet I, Kennedy S, and Hahn M. 2003. Gonadal feminization and halogenated ecology contaminants in mutual terns (Sterna hirundo): Evidence that ovotestes in male person embryos do not persist to the prefledgling stage. Ecotoxicology 12:125-140. Hayes T, Hason Thou, Tsui K, Hoang A, Haeffele C, and Vonk A. 2003. Atrazine-induced hermaphroditism at 0.i ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence. Ecology Wellness Perspectives 111:568-575. Hewitt Chiliad, Smyth S, Dube K, Gilman C, and MacLatchy D. 2002. Isolation of compounds from bleached kraft factory recovery condensates associated with reduced levels of testosterone in mummichog (Fundulus heteroclitus). Environmental Toxicology and Chemical science 21:1359-1367. Howell WM, Black DA, and Bortone SA. 1980. Abnormal expression of secondary sex characters in a population of mosquitofish, Gambusia affinis holbrooki:  Evidence for environmentally-induced masculinization. Copeia four:676-681. Jenkins R, Angus R, McNatt H, Howell W, Kemppainen J, Kirk M, and Wilson E. 2001. Identification of androstenedione in a river containing paper manufacturing plant effluent. Environmental Toxicology and Chemistry twenty:1325-1331. Jenkins R, Wilson E, Angus R, Howell W, and Kirk M. 2003. Androstenedione and progesterone in the sediment of a river receiving newspaper mill effluent. Toxicological Sciences 73:53-59. Jobling S and Sumpter JP. 1993. Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology 27:361-372. Jobling S, Nolan M, Tyler CR, Brighty G, and Sumpter JP. 1998. Widespread sexual disruption in wild fish. Environmental Science and Technology 32:2498-2506. Jobling S, Beresford Due north, Nolan One thousand, Rodgers-Grayness T, Brighty One thousand, Sumpter J, and Tyler C. 2002a. Altered sexual maturation and gamete product in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biology of Reproduction 66:272-281. Jobling S, Coey Southward, Whitmore J, Kime D, VanLook Thousand, McAllister B, Beresford N, Henshaw A, Brighty Thousand, Tyler C, and Sumpter J. 2002b. Wild intersex roach (Rutilus rutilus) accept reduced fertility. Biological science of Reproduction 67:515-524. Kannan Thou, Ueda M, Shelby J, Mendonca M, Kawano Grand, Matsuda G, Wakimoto T, and Giesy J. 2000. Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyl (PCBs), and organochlorine pesticides in yellow-blotched map turtle from the Pascagoula River bain, Mississippi, The states. Archives of Environmental Contamination and Toxicology 38:362-370. Kirby M, Allen Y, Dyer R, Feist S, Katsiadaki I, Matthiessen P, Scott A, Smith A, Stntiford Grand, Thain J, Thomas Grand, Tolhurst L, and Waldock M. 2004. Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contagion in United kingdom estuaries:  Temporal trends, 1996 - 2001. Environmental Toxicology and Chemistry 23:748-758. Le Boeuf B, Giesy J, Kannan K, Kajiwara North, Tanabe S, and Debier C. 2002. Organochloride pesticides in California sea lions revisited. BMC Environmental ii:xi. Lundholm C, 1997. DDE-induced eggshell thinning in birds: Furnishings of p,p'-DDE on the calcium and prostaglandin metabolism of the eggshell gland. Comp Biochem Physiol Pharmacol Toxicol Endocrinol 118:113-128. Matthiessen P, Allen Y, Bamber S, Craft J, Hurst M, Hutchinson T, Feist S, Katsiadaki I, Kirby M, Robinson C, Scott S, Thain J, and Thomas G. 2002. The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom: Summary of the EDMAR program. Marine Ecology Research 54:645-649. Munkittrick 1000, McMaster M, McCarthy L, Servos M, and Van Der Kraak GJ. 1998. An overview of recent studies on the potential of pulp-mill effluents to alter reproductive parameters in fish. Journal of Toxicology and Environmental Wellness Part B 1:347-371. Ormerod S, Tyler South, and Juttner I. 2000. Effects of bespeak-source PCB contagion on breeding functioning and post-fledgling survival in the dipper Cinclus cinclus. Environmental Pollution 110:505-513. Oskam I, Ropstad E, Dahl E, Lie East, Derocher A, Wiig O, Larsen Southward, Wiger R, and Skaare J. 2003. Organochlorines affect the major androgenic hormone, testosterone in male person polar bears (Ursus maritimus) at Svalbard. Periodical of Toxicology and Environmental Health Part A 66:2119-2139. Oskam I, Ropstad E, Lie E, Derocher A, Wiig O, Dahl E, Larsen S, and Skaare J. 2004. Organochlorines affect the steroid hormone cortisol in the free-ranging polar bears (Ursus maritimus) in Svalbard, Norway. Journal of Toxicology and Environmental Health Part A 67:959-977. Reeder A, Ruiz Grand, Pessier A, Brown 50, Levengood J, Phillips C, Wheeler M, Warner R, and Beasley V. 2005. Intersexuality and the cricket frog pass up: Historic and geographic trends. Ecology Health Perspectives 113:261-265. Reijnders P. 1986. Reproductive failure in common seals feeding on fish from polluted coastal waters. Nature 324:456-457, erratum p. 418. Routledge EJ, Sheahan D, Desbrow C, Brightly GC, Waldock M, and Sumpter JP. 1998. Identification of estrogenic chemicals in STW effluent. 2. In vivo responses in trout and roach. Environmental Scientific discipline and Applied science 32:1559-1565. Sheahan D, Brighty Grand, Daniel Chiliad, Jobling S, Harries J, Hurst Yard, Kennedy J, Kirby S, Morris Due south, Routledge E, Sumpter J, and Waldock M, 2002. Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river equally a result of a decrease in the concentration of industrially derived surfactants. Environmental Toxicology and Chemistry 21:515-519. Shelby J and Mendonca Grand. 2001. Comparison of reproductive parameters in male yellowish-blotched map turtles (Graptemys flavimaculata) from a historically contaminated and a reference site. Comparative Biochemistry and Physiology. C. Toxicology and Pharmacology 129:233-242. Skaare J, Bernhoft A, Wiig O, Norum 1000, Haug E, Eide D, and Derocher A. 2001. Relationships betwixt plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. Periodical of Toxicology and Environmental Wellness Role A 62:227-241. Tanabe S. 2002. Contagion and toxic effects of persistent endocrine disrupters in marine mammals and birds. Marine Pollution Bulletin 45:69-77. Wiig O. 1998. Survival and reproductive rates for polar bears at Svalbard. Ursus 10:25-32. Willingham Due east and Crews D. 1999. Sex reversal effects of environmentally relevant pesticide concentrations on the red-eared slider turtle, a species with temperature-dependent sexual practice determination. General Comparative Endocrinology 113:429-435. Willingham Due east, Turk Rhen T, Jon T. Sakata JT, and Crews D. 2000. Embryonic Treatment with Xenobiotics Disrupts Steroid Hormone Profiles in Hatchling Red-Eared Slider Turtles (Trachemys scripta elegans). Environmental Wellness Perspectives 108:329-332. back to meridian

Source: http://e.hormone.tulane.edu/learning/wildlife-effects.html

Posted by: salazarexions.blogspot.com

Share this post